Changes in the Titre of Serum Opsonins and Phagocytic Properties of Mouse Peritoneal Macrophages following Injection of Endotoxin
نویسندگان
چکیده
A study has been made of the changes in the opsonic properties of mouse serum and bactericidal activity of mouse peritoneal macrophages at different times following the injection of various doses of lipopolysaccharide. It has been found that changes in the percentage of bacteria phagocytosed and killed within the mouse peritoneal cavity in a given time could be correlated with changes in the opsonic titre of the serum. Macrophages harvested from the peritoneal cavities of mice injected with endotoxin appear to be more efficient in phagocytosing bacteria in the presence of serum opsonins than macrophages obtained from normal mice. The relative importance of these changes in determining an animal's resistance to infection is discussed.
منابع مشابه
Changes in T H E T I T R E of Serum Opsonins and Phagocytic Properties of Mouse Peritoneal Macrophages following Injection of Endotoxin* by Charles Jenkin,~
I t is a well established fact that the lipopolysaccharide component of cell walls of Gram-negative bacteria alters the resistance of mice to infections by bacterial and viral agents (1-4). Depending on the amount of lipopolysaccharide endotoxin injected and the time of challenge, the outcome of this treatment may either increase or decrease the natural resistance of the mouse to experimental i...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 112 شماره
صفحات -
تاریخ انتشار 1960